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<DIV class=Section1>
<P class=MsoNormal
style="MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; TEXT-ALIGN: center; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto"
align=center><B style="mso-bidi-font-weight: normal"><I><FONT face=Arial
color=#660000 size=4><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; FONT-SIZE: 14pt; COLOR: #660000; FONT-STYLE: italic; mso-bidi-font-weight: normal; mso-bidi-font-size: 12.0pt; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">CICLOS
DE CHARLAS EN EL INSTITUTO DE MATEMÁTICA APLICADA SAN
LUIS</SPAN></FONT></I></B><FONT size=4><SPAN lang=ES-AR
style="FONT-SIZE: 14pt; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">
<BR></SPAN></FONT><B style="mso-bidi-font-weight: normal"><I><FONT
color=#660000><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; COLOR: #660000; FONT-STYLE: italic; mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">(IMASL)</SPAN></FONT></I></B><SPAN
lang=ES-AR style="mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">
</SPAN><SPAN lang=ES-AR
style="mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR; mso-fareast-font-family: 'Arial Unicode MS'"><o:p></o:p></SPAN></P>
<P style="MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; TEXT-ALIGN: center"
align=center><![if !supportEmptyParas]><![endif]><FONT face=Arial size=2><SPAN
lang=ES-AR
style="FONT-SIZE: 10pt; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">
<HR style="WIDTH: 659px; HEIGHT: 2px" SIZE=2>
</P>
<DIV class=MsoNormal
style="MARGIN-LEFT: 72pt; MARGIN-RIGHT: 72pt; TEXT-ALIGN: center; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto"
align=center><FONT size=3> </FONT></SPAN></FONT></DIV>
<P class=MsoCaption align=center><B style="mso-bidi-font-weight: normal"><FONT
face=Arial size=4><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; FONT-SIZE: 14pt; mso-bidi-font-weight: normal"><SPAN
style="mso-bidi-font-size: 10.0pt"><SPAN
style="mso-spacerun: yes"> </SPAN></SPAN></SPAN></FONT></B><FONT
face=Arial size=3><SPAN lang=ES-AR
style="FONT-SIZE: 12pt; mso-ansi-language: ES-AR"><FONT
face="Times New Roman"><STRONG>Para público en general y todos los
estudiantes de disciplinas afines a esta temática: Física,
Química, Biología, Biología Molecular, y
Farmacia.<o:p></o:p></STRONG></FONT></SPAN></FONT><FONT
face="Arial Unicode MS"><SPAN lang=ES-AR
style="FONT-FAMILY: 'Arial Unicode MS'; mso-ansi-language: ES-AR; mso-fareast-font-family: 'Times New Roman'"><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><B
style="mso-bidi-font-weight: normal"><U><FONT face=Arial size=3><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">Título</SPAN></FONT></U></B><SPAN
lang=ES-AR
style="mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">: </SPAN><SPAN
lang=ES-AR style="mso-ansi-language: ES-AR"> </SPAN></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"
align=center><SPAN lang=ES-AR style="mso-ansi-language: ES-AR"></SPAN><FONT
face="Arial Unicode MS"><SPAN lang=ES-AR
style="FONT-FAMILY: 'Arial Unicode MS'; mso-ansi-language: ES-AR; mso-fareast-font-family: 'Times New Roman'"><o:p>
<FONT face=Arial size=2> <FONT size=6> <FONT
color=#ff00ff>"DESPLAZAMIENTOS QUÍMICOS: UNA HERRAMIENTA PARA VALIDAR Y
DETERMINAR ESTRUCTURAS DE
PROTEÍNAS"</FONT></FONT></FONT></o:p></SPAN></FONT></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; TEXT-ALIGN: center; mso-margin-top-alt: 0cm"
align=center><FONT face=Arial color=#ff6600 size=6><SPAN lang=ES-AR
style="FONT-SIZE: 24pt; COLOR: #ff6600; mso-bidi-font-size: 12.0pt; mso-ansi-language: ES-AR"><SPAN
style="mso-spacerun: yes"> </SPAN></SPAN></FONT><FONT
face="Arial Unicode MS" color=#ff6600 size=6><SPAN lang=ES-AR
style="FONT-SIZE: 24pt; COLOR: #ff6600; FONT-FAMILY: 'Arial Unicode MS'; mso-bidi-font-size: 12.0pt; mso-ansi-language: ES-AR; mso-fareast-font-family: 'Times New Roman'"><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><B
style="mso-bidi-font-weight: normal"><U><FONT face=Arial size=3><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">Expone</SPAN></FONT></U></B><SPAN
lang=ES-AR style="mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">:
<STRONG>Dr. Jorge VILA</STRONG></SPAN><STRONG><FONT face=Arial size=3><SPAN
lang=ES-AR
style="FONT-SIZE: 12pt; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"> </SPAN></FONT><SPAN
lang=ES-AR style="mso-ansi-language: ES-AR"> </SPAN><FONT
face="Arial Unicode MS"><SPAN lang=ES-AR
style="FONT-FAMILY: 'Arial Unicode MS'; mso-ansi-language: ES-AR; mso-fareast-font-family: 'Times New Roman'"><o:p></o:p></SPAN></FONT></STRONG></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; TEXT-INDENT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><STRONG><FONT
face=Arial size=3><SPAN lang=ES-AR
style="FONT-SIZE: 12pt; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"><SPAN
style="mso-tab-count: 3">
</SPAN></SPAN></FONT><SPAN lang=ES-AR style="mso-ansi-language: ES-AR"><SPAN
style="mso-spacerun: yes"> </SPAN></SPAN><SPAN lang=ES-AR
style="mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"><o:p></o:p></SPAN></STRONG></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><B
style="mso-bidi-font-weight: normal"><U><FONT face=Arial size=3><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"></SPAN></FONT></U></B> </P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><B
style="mso-bidi-font-weight: normal"><U><FONT face=Arial size=3><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">Lugar</SPAN></FONT></U></B><SPAN
lang=ES-AR style="mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">:<SPAN
style="mso-spacerun: yes"> <STRONG>Laboratorio de
Matemática (L.I.A.E.M.) - Bloque</STRONG>
<STRONG>II</STRONG></SPAN></SPAN></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><SPAN
lang=ES-AR style="mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"><SPAN
style="mso-spacerun: yes"><STRONG>(1º Laboratorio, a mano
izquierda)</STRONG></SPAN><![if !supportEmptyParas]><![endif]></SPAN></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><SPAN
lang=ES-AR style="mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"><SPAN
style="mso-spacerun: yes"></SPAN></SPAN> </P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><SPAN
lang=ES-AR style="mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"><SPAN
style="mso-spacerun: yes"></SPAN></SPAN> </P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><SPAN
lang=ES-AR style="mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"><SPAN
style="mso-spacerun: yes"></SPAN></SPAN><B
style="mso-bidi-font-weight: normal"><U><FONT face=Arial size=3><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">Fecha</SPAN></FONT></U></B><B
style="mso-bidi-font-weight: normal"><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">:<SPAN
style="mso-spacerun: yes"> </SPAN>Viernes <U> 15 de
Junio de 2007 </U></SPAN></B></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><B
style="mso-bidi-font-weight: normal"><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"><U></U></SPAN></B> </P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><B
style="mso-bidi-font-weight: normal"><SPAN lang=ES-AR
style="FONT-WEIGHT: bold; mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"><U>Hora:</U> 11:00<SPAN
style="mso-spacerun: yes"> </SPAN>hs.</SPAN></B><SPAN lang=ES-AR
style="mso-ansi-language: ES-AR"> </SPAN><FONT face="Arial Unicode MS"><SPAN
lang=ES-AR
style="FONT-FAMILY: 'Arial Unicode MS'; mso-ansi-language: ES-AR; mso-fareast-font-family: 'Times New Roman'"><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><FONT
face=Arial size=3><SPAN lang=ES-AR
style="FONT-SIZE: 12pt; mso-ansi-language: ES-AR"> </SPAN></FONT><FONT
face="Arial Unicode MS"><SPAN lang=ES-AR
style="FONT-FAMILY: 'Arial Unicode MS'; mso-ansi-language: ES-AR; mso-fareast-font-family: 'Times New Roman'"><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; TEXT-ALIGN: justify; mso-margin-top-alt: 0cm"><FONT
face=Arial size=3><SPAN lang=ES-AR
style="FONT-SIZE: 12pt; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR"><![if !supportEmptyParas]><![endif]> <o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal
style="MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 36pt; MARGIN-RIGHT: 36pt; mso-margin-top-alt: 0cm"><B
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style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; mso-bidi-font-weight: normal; mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">Resumen</SPAN></FONT></U></B><SPAN
lang=ES-AR
style="mso-bidi-font-family: Arial; mso-ansi-language: ES-AR">: </SPAN><SPAN
lang=ES-AR style="mso-ansi-language: ES-AR"> </SPAN><FONT
face="Arial Unicode MS"><SPAN lang=ES-AR
style="FONT-FAMILY: 'Arial Unicode MS'; mso-ansi-language: ES-AR; mso-fareast-font-family: 'Times New Roman'"><o:p></o:p></SPAN></FONT></P><![if !supportLineBreakNewLine]><![endif]><![if !supportEmptyParas]><![endif]>
<P class=MsoBodyTextIndent><FONT face=Arial><SPAN
style="FONT-WEIGHT: normal; FONT-FAMILY: Arial; mso-bidi-font-weight: bold; mso-ansi-language: ES">.</P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%; TEXT-ALIGN: justify"
align=justify><SPAN lang=ES-AR style="mso-ansi-language: ES-AR"><FONT
face="Times New Roman"> Nuestro
objetivo es ilustrar como los desplazamientos químicos de los
<SUP>13</SUP>C</FONT></SPAN><SUP><SPAN lang=ES-AR
style="FONT-FAMILY: Symbol; mso-ansi-language: ES-AR">a</SPAN></SUP><SPAN
lang=ES-AR style="mso-ansi-language: ES-AR"><FONT face="Times New Roman"> nos
proveen con la información necesaria para <B
style="mso-bidi-font-weight: normal">validar y determinar, </B>con exactitud,
estructuras de proteínas. Primero haremos un análisis
de la validación de 139 modelos de la proteína <I
style="mso-bidi-font-style: normal">Ubiquitin</I> (conocida como “el beso de la
muerte”). Luego </FONT></SPAN><SPAN lang=ES-AR
style="mso-ansi-language: ES-AR"><FONT face="Times New Roman">mostraremos como
la metodología puede también usarse para generar modelos tridimensionales de
estructuras </FONT></SPAN><SPAN lang=ES-AR
style="mso-ansi-language: ES-AR"><FONT face="Times New Roman">de proteínas.
Específicamente mostraremos que, partiendo de una conformación ‘<I
style="mso-bidi-font-style: normal">arbitraria</I>’ de 76 amino
</FONT></SPAN><SPAN lang=ES-AR style="mso-ansi-language: ES-AR"><FONT
face="Times New Roman">ácidos (correspondientes a la secuencia de la proteína <I
style="mso-bidi-font-style: normal">Bacillus subtilis acyl carrier</I>), el
nuevo método</FONT></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%; TEXT-ALIGN: justify"
align=justify><SPAN lang=ES-AR style="mso-ansi-language: ES-AR"><FONT
face="Times New Roman">permite encontrar modelos más exactos que el existente
(depositado en el <I style="mso-bidi-font-style: normal">Protein Data Bank</I>
bajo el código 1HY8).<o:p></o:p></FONT></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%; TEXT-ALIGN: justify"
align=justify><SPAN lang=ES-AR style="mso-ansi-language: ES-AR"><FONT
face="Times New Roman"> <o:p></o:p></FONT></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 150%; TEXT-ALIGN: justify"><SPAN
lang=ES-AR style="mso-ansi-language: ES-AR"><FONT
face="Times New Roman"> <STRONG><U>Currículo Vital del Dr. Jorge A.
Vila<BR></U></STRONG>
Es: Profesor Adjunto del Departamento de Física
(FCFMyN- UNSL);
</FONT></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 150%; TEXT-ALIGN: justify"><SPAN
lang=ES-AR style="mso-ansi-language: ES-AR"><FONT
face="Times New Roman"> Investigador Independiente del CONICET;
</FONT></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 150%; TEXT-ALIGN: justify"><SPAN
lang=ES-AR style="mso-ansi-language: ES-AR"><FONT
face="Times New Roman"> Miembro del IMASL e Investigador Asociado en la
Universidad
de
Cornell (USA). </FONT></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 150%; TEXT-ALIGN: justify"><SPAN
lang=ES-AR style="mso-ansi-language: ES-AR"><FONT
face="Times New Roman"> Ha sido: Secretario de Ciencia y Técnica de la
UNSL;<BR> Decano
de la FCFMyN; </FONT></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 150%; TEXT-ALIGN: justify"><SPAN
lang=ES-AR style="mso-ansi-language: ES-AR"><FONT
face="Times New Roman">Visitante Científico y Profesor Visitante del Departamento de Química
de la Universidad
de Cornell (USA); y Miembro Asociado del
Centro
Internacional de Física Teórica (ICTP),</FONT></SPAN><SPAN lang=ES-AR
style="mso-ansi-language: ES-AR"><FONT face="Times New Roman"> Trieste,
Italia. </FONT></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 150%; TEXT-ALIGN: justify"><SPAN
lang=ES-AR style="mso-ansi-language: ES-AR"><FONT
face="Times New Roman"> Sus trabajos científicos, han sido publicados en
variadas revistas
nacionales e
internacionales.<BR></P><o:p></o:p></FONT></SPAN>
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